Regulatory T‐cell gene expression: ChIP'ing away at Foxp3
نویسندگان
چکیده
منابع مشابه
Key Regulatory Gene Expression in Erythroleukemia Differentiation
The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...
متن کاملChIPping away at gene regulation.
The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding...
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patients and methods in this cross-sectional study, peripheral mononuclear cells (pbmcs) were isolated from peripheral blood of 29 patients with newly diagnosed pulmonary tb and 19 patients with positive tuberculin skin test. the pbmcs were activated with ppd for 72 hours. activated cells were harvested, rna was extracted and cdna was synthesized. a real-time taqman method was designed and opti...
متن کاملkey regulatory gene expression in erythroleukemia differentiation
the characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. in this report we characterise a leukemic model, d5a1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. cells induced with 4 mm hexamethylene bisacetamide (hmba) caused signs...
متن کاملAssociation of FOXP3 regulatory gene expression with systemic lupus erythematosus disease activity among Egyptian patients.
The concept that regulatory T cells (Treg) play a key role in both development and maintenance of autoimmune response in rheumatological diseases is well accepted. In recent years, several studies analyzed Treg cell phenotype and function in systemic lupus erythematosus (SLE), the prototypical systemic autoimmune disorder in humans. The forkhead family transcription factor FOXP3 currently repre...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2007
ISSN: 0818-9641,1440-1711
DOI: 10.1038/sj.icb.7100051